调节性T细胞(Regulatory t cell, Treg cell)是一类控制体内自身免疫反应性的T细胞亚群,在维持机体免疫系统功能平衡,调节机体免疫耐受和对抗炎症反应中具有至关重要的作用。Treg细胞自身稳态和功能的异常与自身免疫疾病、过敏、慢性感染和肿瘤等疾病密切相关,是近年来免疫学领域研究的热点。
2020年10月27日,加州大学圣地亚哥分校医学院,联合法国图卢兹大学和康涅狄格大学卫生院的科学家在Journal of Experimental Medicine(JEM) 上在线发表了题为Distinct Integrin Activation Pathways for Effector and Regulatory T cell Trafficking and Function的工作(来自作者为孙昊博士)。
该研究揭示,不同于对Teff细胞的调控,整合素活化可以通过独特的信号通路调控Treg细胞的功能。通过对多种免疫性肠炎小鼠模型的研究,作者发现抑制信号通路中的RIAM可以抑制Teff细胞加重炎症反应的作用,同时不影响Treg细胞抑制炎症反应的功能,从而更精准的治疗炎症性肠炎(IBD)或其他自身免疫性疾病【1】。通过对多种与人类IBD相似的免疫肠炎小鼠模型的研究,作者发现抑制RIAM确实极大的缓解小鼠的疾病进程,并且没有副作用产生,从而实现更精准的治疗炎症性肠炎(IBD)或其他自身免疫性疾病。
RIAM在肠道炎症中的功能示意图
在实验中为从结肠中分离总RNA,前处理这块孙博士选用了上海净信JXFSTRP-24这款仪器。
原文链接:https://rupress.org/jem/article-abstract/218/2/e20201524/211498/Distinct-integrin-activation-pathways-for-effector?redirectedFrom=fulltext
上海净信的仪器不止一次出现在孙博士的实验中,另有两篇高分论文孙博士也使用了上海净信的仪器。
Journal of Experimental Medicine(JEM)实验医学期刊和 Journal of cell biology 细胞生物学杂志都是百年期刊。撰写一篇格式规范、内容严谨的科研论文并非易事,每一步都需要科研人员的严谨投入。包括实验仪器的筛选,也绝非随意。
上海净信依托强大的研发和生产服务能力,多年来已成功为数万个实验室提供服务。目前已经在国内外杂志上发表相关论文达1300多篇,其中几百篇发表在高水平SCI杂志上。净信到目前为止已经拥有五代研磨仪产品,随着科研的进步和技术的改变,净信一直会紧跟脚步不断对现有的产品进行技术改善,并创造出更多新的产品,以期更好的为广大科研工作者服务!
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